Young doctor John Dorian just graduated from medical school. The friendly, naive and funny, he gets an internship in a very strange, but the talented and charismatic Dr. Cox. Side by side with the young hero works his best friend and humorist Christopher Turk. Young doctors working in different departments of the hospital, but all the troubles and joys, as well as a house divided equally. Charming, but a bit unbalanced and insecure intern Elliot Reid takes the lion's share of disparaging irony Dr. Cox. Ebony babe Carla, performing duties senior nurse, extraordinary cleaner, the head physician of Bob Kelso help or accidentally put obstacles in the way of heroes growing up and gaining important experience.
Plunging into the wild world of the clinic and medical practice, John Dorian and other interns are faced not only with medical problems, but also with a rigid and rather ironic manner of training sophisticated doctors Cox. Charismatic and inflexibility mentor makes doing complicated professional and moral choices over and over again, literally nurturing young talents. Ahead of the young and inexperienced interns are lots of fun, hilarious and sometimes sad, instructive and even dramatic situations in life that somehow fill routine every doctor.